Reaction Details
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Corticotropin-releasing factor-binding protein
Ligand
BDBM90092
Substrate
n/a
IC50
4640±n/a nM
Citation
PubChem, PC Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format PubChem Bioassay (2012)[AID] More Info.:
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
Inhibitor
Name:
BDBM90092
Synonyms:
MLS000332372 | N-[4-(4-Methoxy-phenyl)-thiazol-2-yl]-2-(3-methylsulfanyl-[1,2,4]thiadiazol-5-ylsulfanyl)-acetamide | N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-2-[(3-methylsulfanyl-1,2,4-thiadiazol-5-yl)sulfanyl]acetamide | N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-2-[(3-methylsulfanyl-1,2,4-thiadiazol-5-yl)sulfanyl]ethanamide | N-[4-(4-methoxyphenyl)-2-thiazolyl]-2-[[3-(methylthio)-1,2,4-thiadiazol-5-yl]thio]acetamide | N-[4-(4-methoxyphenyl)thiazol-2-yl]-2-[[3-(methylthio)-1,2,4-thiadiazol-5-yl]thio]acetamide | SMR000221674 | cid_1840505
Type:
Small organic molecule
Emp. Form.:
C15H14N4O2S4
Mol. Mass.:
410.557
SMILES:
COc1ccc(cc1)-c1csc(NC(=O)CSc2nc(SC)ns2)n1
Structure:
