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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM78182
Substrate
n/a
IC50
5100±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM78182
Synonyms:
2-(3,4-dichlorophenyl)-N'-[(3,4-dimethoxybenzoyl)oxy]ethanimidamide | 3,4-dimethoxybenzoic acid [(Z)-[1-amino-2-(3,4-dichlorophenyl)ethylidene]amino] ester | MLS000578928 | SMR000198749 | [(Z)-[1-amino-2-(3,4-dichlorophenyl)ethylidene]amino] 3,4-dimethoxybenzoate | [(Z)-[1-azanyl-2-(3,4-dichlorophenyl)ethylidene]amino] 3,4-dimethoxybenzoate | cid_9587530
Type:
Small organic molecule
Emp. Form.:
C17H16Cl2N2O4
Mol. Mass.:
383.226
SMILES:
COc1ccc(cc1OC)C(=O)ON=C(N)Cc1ccc(Cl)c(Cl)c1 |w:13.13|
Structure:
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