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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM90463
Substrate
n/a
IC50
2360±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM90463
Synonyms:
8-[4-(dimethylamino)benzylidene]-6,10-dioxaspiro[4.5]decane-7,9-quinone | 8-[[4-(dimethylamino)phenyl]methylidene]-6,10-dioxaspiro[4.5]decane-7,9-dione | MLS000678321 | SMR000285277 | cid_765996
Type:
Small organic molecule
Emp. Form.:
C17H19NO4
Mol. Mass.:
301.3371
SMILES:
[#6]-[#7](-[#6])-c1ccc(\[#6]=[#6]-2/[#6](=O)-[#8]C3([#6]-[#6]-[#6]-[#6]3)[#8]-[#6]-2=O)cc1
Structure:
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