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Target
Perilipin-5
Ligand
BDBM94505
Substrate
n/a
IC50
1778±n/a nM
Citation
 PubChem, PC Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) PubChem Bioassay (2012)[AID] 
Target
Name:
Perilipin-5
Synonyms:
LSDP5 | OXPAT | PAT-1 | PLIN5 | PLIN5_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50774.20
Organism:
Homo sapiens (Human)
Description:
gi_116292172
Residue:
463
Sequence:
MSEEEAAQIPRSSVWEQDQQNVVQRVVALPLVRATCTAVCDVYSAAKDRHPLLGSACRLAENCVCGLTTRALDHAQPLLEHLQPQLATMNSLACRGLDKLEEKLPFLQQPSETVVTSAKDVVASSVTGVVDLARRGRRWSVELKRSVSHAVDVVLEKSEELVDHFLPMTEEELAALAAEAEGPEVGSVEDQRRQQGYFVRLGSLSARIRHLAYEHSVGKLRQSKHRAQDTLAQLQETLELIDHMQCGVTPTAPACPGKVHELWGEWGQRPPESRRRSQAELETLVLSRSLTQELQGTVEALESSVRGLPAGAQEKVAEVRRSVDALQTAFADARCFRDVPAAALAEGRGRVAHAHACVDELLELVVQAVPLPWLVGPFAPILVERPEPLPDLADLVDEVIGGPDPRWAHLDWPAQQRAWEAEHRDGSGNGDGDRMGVAGDICEQEPETPSCPVKHTLMPELDF
  
Inhibitor
Name:
BDBM94505
Synonyms:
MLS003107617 | N-(2-thienyl)carbamic acid [(2S,3R,4R)-6,9-diketo-4-[[propargyl(tosyl)amino]methyl]-3-(2-thienylcarbamoyloxy)-1,2,3,4-tetrahydropyridazino[1,2-a]pyridazin-2-yl] ester | N-thiophen-2-ylcarbamic acid [(2S,3R,4R)-4-[[(4-methylphenyl)sulfonyl-prop-2-ynylamino]methyl]-6,9-dioxo-3-[oxo-(thiophen-2-ylamino)methoxy]-1,2,3,4-tetrahydropyridazino[1,2-a]pyridazin-2-yl] ester | SMR001822612 | [(2S,3R,4R)-4-[[(4-methylphenyl)sulfonyl-prop-2-ynyl-amino]methyl]-6,9-bis(oxidanylidene)-3-(thiophen-2-ylcarbamoyloxy)-1,2,3,4-tetrahydropyridazino[1,2-a]pyridazin-2-yl] N-thiophen-2-ylcarbamate | [(2S,3R,4R)-4-[[(4-methylphenyl)sulfonyl-prop-2-ynylamino]methyl]-6,9-dioxo-3-(thiophen-2-ylcarbamoyloxy)-1,2,3,4-tetrahydropyridazino[1,2-a]pyridazin-2-yl] N-thiophen-2-ylcarbamate | cid_46903217
Type:
Small organic molecule
Emp. Form.:
C29H27N5O8S3
Mol. Mass.:
669.748
SMILES:
Cc1ccc(cc1)S(=O)(=O)N(CC#C)C[C@@H]1[C@@H](OC(=O)Nc2cccs2)[C@H](Cn2n1c(=O)ccc2=O)OC(=O)Nc1cccs1
Structure:
Search PDB for entries with ligand similarity: