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Target
Protein O-GlcNAcase
Ligand
BDBM77047
Substrate
n/a
Meas. Tech.
Cell-based ELISA
Temperature
277.1500±n/a K
EC50
29±n/a nM
Comments
extracted
Citation
 Kaul, R; McEachern, EJ; Vocadlo, DJ; Zhou, Y; Dang, Q; Selnick, HG Glycosidase inhibitors and uses thereof US Patent  US9695197 Publication Date 7/4/2017 
Target
Name:
Protein O-GlcNAcase
Synonyms:
Beta-N-acetylhexosaminidase | O-glycoprotein 2-acetamido-2-deoxy-β-D-glucopyranosidase (O-GlcNAcase) | Beta-hexosaminidase (O-GlcNAcase) | 2-acetamido-2-deoxy-β-D-glucopyranosidase (O-GlcNAcase) | Bifunctional protein NCOAT | Protein O-GlcNAcase | OGA_HUMAN | OGA | HEXC | KIAA0679 | MEA5 | MGEA5 | N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)
Type:
Enzyme
Mol. Mass.:
102874.67
Organism:
Human
Description:
O60502
Residue:
916
Sequence:
MVQKESQATLEERESELSSNPAASAGASLEPPAAPAPGEDNPAGAGGAAVAGAAGGARRFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPNVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMTDSEDSTVSIQIKLENEGSDEDIETDVLYSPQMALKLALTEWLQEFGVPHQYSSRQVAHSGAKASVVDGTPLVAAPSLNATTVVTTVYQEPIMSQGAALSGEPTTLTKEEEKKQPDEEPMDMVVEKQEETDHKNDNQILSEIVEAKMAEELKPMDTDKESIAESKSPEMSMQEDCISDIAPMQTDEQTNKEQFVPGPNEKPLYTAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKDSEKIEEWRSRAAKFEEMCGLVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQWLGCRSHSSAQFLIGDQEPWAFRGGLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPYFPKDEASVYKICREMYDDGVGLPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYALGTVDVTPFIKKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFPSLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIAKMEGFPKDVVILGRSL
  
Inhibitor
Name:
BDBM77047
Synonyms:
US9695197, 3
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CCCNC1=N[C@H]2[C@@H](S1)S[C@H](CO)[C@@H](O)[C@@H]2O |r,t:4|
Structure:
Search PDB for entries with ligand similarity: