Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
Ligand
BDBM82761
Substrate
n/a
IC50
10899±n/a nM
Citation
PubChem, PC Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1) PubChem Bioassay (2012)[AID] More Info.:
Target
Name:
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
Synonyms:
ASAP1 | ASAP1_HUMAN | DDEF1 | KIAA1249 | PAG2 | arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
125507.11
Organism:
Homo sapiens (Human)
Description:
Q9ULH1
Residue:
1129
Sequence:
MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKEDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD
Inhibitor
Name:
BDBM82761
Synonyms:
2,3-Dihydro-benzo[1,4]dioxine-6-carboxylic acid [1-(4-chloro-3-nitro-phenyl)-meth-(E)-ylidene]-hydrazide | MLS000587937 | N-[(4-chloranyl-3-nitro-phenyl)methylideneamino]-2,3-dihydro-1,4-benzodioxine-6-carboxamide | N-[(4-chloro-3-nitro-benzylidene)amino]-2,3-dihydro-1,4-benzodioxin-6-carboxamide | N-[(4-chloro-3-nitrophenyl)methylideneamino]-2,3-dihydro-1,4-benzodioxin-6-carboxamide | N-[(4-chloro-3-nitrophenyl)methylideneamino]-2,3-dihydro-1,4-benzodioxine-6-carboxamide | N-[(E)-(4-chloro-3-nitro-benzylidene)amino]-2,3-dihydro-1,4-benzodioxin-6-carboxamide | SMR000211981 | cid_3707986
Type:
Small organic molecule
Emp. Form.:
C16H12ClN3O5
Mol. Mass.:
361.737
SMILES:
[O-][N+](=O)c1cc(\C=N\NC(=O)c2ccc3OCCOc3c2)ccc1Cl
Structure:
