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Target
Sentrin-specific protease 1
Ligand
BDBM94795
Substrate
n/a
IC50
23100±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a FRET assay PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
  
Inhibitor
Name:
BDBM94795
Synonyms:
(6E)-6-[[[4-(2-furanyl)-2-(3-pyridinylimino)-3-thiazolyl]amino]methylidene]-4-methoxy-1-cyclohexa-2,4-dienone | (6E)-6-[[[4-(2-furyl)-2-(3-pyridylimino)-4-thiazolin-3-yl]amino]methylene]-4-methoxy-cyclohexa-2,4-dien-1-one | (6E)-6-[[[4-(furan-2-yl)-2-pyridin-3-ylimino-1,3-thiazol-3-yl]amino]methylidene]-4-methoxy-cyclohexa-2,4-dien-1-one | (6E)-6-[[[4-(furan-2-yl)-2-pyridin-3-ylimino-1,3-thiazol-3-yl]amino]methylidene]-4-methoxycyclohexa-2,4-dien-1-one | MLS000417017 | SMR000241891 | cid_6511422
Type:
Small organic molecule
Emp. Form.:
C20H16N4O3S
Mol. Mass.:
392.431
SMILES:
COc1ccc(O)c(C=Nn2c(csc2=Nc2cccnc2)-c2ccco2)c1 |w:9.9,15.16|
Structure:
Search PDB for entries with ligand similarity: