Reaction Details Report a problem with these data
Target
Sentrin-specific protease 1
Ligand
BDBM75794
Substrate
n/a
IC50
13000±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a kinetic FRET assay PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
  
Inhibitor
Name:
BDBM75794
Synonyms:
5-(5-chloranyl-2-oxidanyl-phenyl)carbonyl-1-(1,5-dimethyl-3-oxidanylidene-2-phenyl-pyrazol-4-yl)-2-oxidanylidene-pyridine-3-carbonitrile | 5-(5-chloro-2-hydroxy-benzoyl)-2-keto-1-(3-keto-1,5-dimethyl-2-phenyl-3-pyrazolin-4-yl)nicotinonitrile | 5-(5-chloro-2-hydroxybenzoyl)-1-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-oxopyridine-3-carbonitrile | 5-[(5-chloro-2-hydroxyphenyl)-oxomethyl]-1-(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)-2-oxo-3-pyridinecarbonitrile | MLS000565095 | SMR000152353 | cid_4395462
Type:
Small organic molecule
Emp. Form.:
C24H17ClN4O4
Mol. Mass.:
460.869
SMILES:
Cc1c(-n2cc(cc(C#N)c2=O)C(=O)c2cc(Cl)ccc2O)c(=O)n(-c2ccccc2)n1C |(4.37,-1.92,;5.84,-2.39,;7.08,-1.49,;7.08,.05,;8.41,.82,;8.41,2.36,;7.08,3.13,;5.75,2.36,;4.41,3.13,;3.08,3.9,;5.75,.82,;4.41,.05,;9.75,3.13,;11.08,2.36,;9.75,4.67,;8.41,5.44,;8.41,6.98,;7.08,7.75,;9.75,7.75,;11.08,6.98,;11.08,5.44,;12.42,4.67,;8.33,-2.39,;9.79,-1.92,;7.85,-3.86,;8.76,-5.1,;8.13,-6.51,;9.04,-7.75,;10.57,-7.59,;11.19,-6.19,;10.29,-4.94,;6.31,-3.86,;5.41,-5.1,)|
Structure:
Search PDB for entries with ligand similarity: