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Target
Sentrin-specific protease 1
Ligand
BDBM94788
Substrate
n/a
IC50
27900±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a kinetic FRET assay PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
  
Inhibitor
Name:
BDBM94788
Synonyms:
2-(4-methoxyphenyl)-6-(2-thenoyl)-3H-pyridazine-3,4-dicarboxylic acid dimethyl ester | 2-(4-methoxyphenyl)-6-[oxo(thiophen-2-yl)methyl]-3H-pyridazine-3,4-dicarboxylic acid dimethyl ester | MLS000700807 | SMR000226597 | cid_11837070 | dimethyl 2-(4-methoxyphenyl)-6-(2-thienylcarbonyl)-2,3-dihydro-3,4-pyridazinedicarboxylate | dimethyl 2-(4-methoxyphenyl)-6-(thiophene-2-carbonyl)-3H-pyridazine-3,4-dicarboxylate | dimethyl 2-(4-methoxyphenyl)-6-thiophen-2-ylcarbonyl-3H-pyridazine-3,4-dicarboxylate
Type:
Small organic molecule
Emp. Form.:
C20H18N2O6S
Mol. Mass.:
414.432
SMILES:
COC(=O)C1N(N=C(C=C1C(=O)OC)C(=O)c1cccs1)c1ccc(OC)cc1 |c:6,8|
Structure:
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