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Target
ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM95216
Substrate
n/a
IC50
83855±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] 
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
  
Inhibitor
Name:
BDBM95216
Synonyms:
MLS000936225 | N-[2-(3-chloroanilino)-2-keto-ethyl]-3-(3,4-dimethoxyphenyl)-4-keto-phthalazine-1-carboxamide | N-[2-(3-chloroanilino)-2-oxoethyl]-3-(3,4-dimethoxyphenyl)-4-oxo-1-phthalazinecarboxamide | N-[2-(3-chloroanilino)-2-oxoethyl]-3-(3,4-dimethoxyphenyl)-4-oxophthalazine-1-carboxamide | N-[2-[(3-chlorophenyl)amino]-2-oxidanylidene-ethyl]-3-(3,4-dimethoxyphenyl)-4-oxidanylidene-phthalazine-1-carboxamide | SMR000620960 | cid_15997541
Type:
Small organic molecule
Emp. Form.:
C25H21ClN4O5
Mol. Mass.:
492.911
SMILES:
COc1ccc(cc1OC)-n1nc(C(=O)NCC(=O)Nc2cccc(Cl)c2)c2ccccc2c1=O
Structure:
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