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Target
ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM95238
Substrate
n/a
IC50
>164734±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] 
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
  
Inhibitor
Name:
BDBM95238
Synonyms:
5-ethoxy-3-methyl-2-benzofurancarboxylic acid [2-(2,6-dimethyl-4-morpholinyl)-2-oxoethyl] ester | 5-ethoxy-3-methyl-coumarilic acid [2-(2,6-dimethylmorpholino)-2-keto-ethyl] ester | MLS002157671 | SMR001240159 | [2-(2,6-dimethylmorpholin-4-yl)-2-oxidanylidene-ethyl] 5-ethoxy-3-methyl-1-benzofuran-2-carboxylate | [2-(2,6-dimethylmorpholin-4-yl)-2-oxoethyl] 5-ethoxy-3-methyl-1-benzofuran-2-carboxylate | cid_16272700
Type:
Small organic molecule
Emp. Form.:
C20H25NO6
Mol. Mass.:
375.4156
SMILES:
CCOc1ccc2oc(C(=O)OCC(=O)N3CC(C)OC(C)C3)c(C)c2c1
Structure:
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