Reaction Details Report a problem with these data
Target
Tumor necrosis factor receptor superfamily member 10B
Ligand
BDBM43724
Substrate
n/a
EC50
10300±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for a small molecule Caspase-8 TRAIL sensitizers in a luminescence panel assay PubChem Bioassay (2013)[AID] 
Target
Name:
Tumor necrosis factor receptor superfamily member 10B
Synonyms:
DR5 | KILLER | TNFRSF10B | TR10B_HUMAN | TRAILR2 | TRICK2 | ZTNFR9 | tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens]
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47869.76
Organism:
Homo sapiens (Human)
Description:
gi_224494019
Residue:
440
Sequence:
MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQDLAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIEDHLLSSGKFMYLEGNADSAMS
  
Inhibitor
Name:
BDBM43724
Synonyms:
(E)-1-(4-chlorophenyl)-3-(3-methoxyanilino)-2-propen-1-one | (E)-1-(4-chlorophenyl)-3-(3-methoxyanilino)prop-2-en-1-one | (E)-1-(4-chlorophenyl)-3-(m-anisidino)prop-2-en-1-one | (E)-1-(4-chlorophenyl)-3-[(3-methoxyphenyl)amino]prop-2-en-1-one | 1-(4-chlorophenyl)-3-[(3-methoxyphenyl)amino]-2-propen-1-one | MLS000686494 | SMR000268150 | cid_2267292
Type:
Small organic molecule
Emp. Form.:
C16H14ClNO2
Mol. Mass.:
287.741
SMILES:
COc1cccc(c1)N=CCC(=O)c1ccc(Cl)cc1 |w:8.8|
Structure:
Search PDB for entries with ligand similarity: