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Target
Rho-associated protein kinase 1 [17-535]
Ligand
BDBM97668
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.2±0
Ki
976±0.0 nM
Citation
 Lampe, JW; Watson, PS; Slade, DJ Bridged bicyclic RHO kinase inhibitor compounds, composition and use US Patent  US8476295 Publication Date 7/2/2013 
Target
Name:
Rho-associated protein kinase 1 [17-535]
Synonyms:
ROCK1 | ROCK1_HUMAN | Rho GDP-dissociation inhibitor 1 | Rho Kinase 1 | Rho-associated protein kinase 1 (ROCK1)
Type:
Protien
Mol. Mass.:
60345.48
Organism:
Homo Sapiens (Human)
Description:
aa 17-535
Residue:
519
Sequence:
LLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQL
  
Inhibitor
Name:
BDBM97668
Synonyms:
US8476295, 3.1.01
Type:
Small organic molecule
Emp. Form.:
C20H22N4
Mol. Mass.:
318.4155
SMILES:
C(N1CC2CCC1C2Nc1ccc2[nH]ncc2c1)c1ccccc1 |TLB:0:1:5.4:7,8:7:1.2:5.4|
Structure:
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