Reaction Details Report a problem with these data
Target
Macrophage colony-stimulating factor 1
Ligand
BDBM97735
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Competition Immunoassay
pH
7.5±0
IC50
3±n/a nM
Citation
 Illig, CR; Ballentine, SK; Chen, J; DesJarlais, RL; Meegalla, SK; Wall, M; Wilson, K Inhibitors of c-fms kinase US Patent  US8481564 Publication Date 7/9/2013 
Target
Name:
Macrophage colony-stimulating factor 1
Synonyms:
CSF1_MOUSE | Csf1 | Csfm | Macrophage colony-stimulating factor 1 (CSF-1)
Type:
Protein
Mol. Mass.:
60631.84
Organism:
Mus musculus (Mouse)
Description:
P07141
Residue:
552
Sequence:
MTARGAAGRCPSSTWLGSRLLLVCLLMSRSIAKEVSEHCSHMIGNGHLKVLQQLIDSQMETSCQIAFEFVDQEQLDDPVCYLKKAFFLVQDIIDETMRFKDNTPNANATERLQELSNNLNSCFTKDYEEQNKACVRTFHETPLQLLEKIKNFFNETKNLLEKDWNIFTKNCNNSFAKCSSRDVVTKPDCNCLYPKATPSSDPASASPHQPPAPSMAPLAGLAWDDSQRTEGSSLLPSELPLRIEDPGSAKQRPPRSTCQTLESTEQPNHGDRLTEDSQPHPSAGGPVPGVEDILESSLGTNWVLEEASGEASEGFLTQEAKFSPSTPVGGSIQAETDRPRALSASPFPKSTEDQKPVDITDRPLTEVNPMRPIGQTQNNTPEKTDGTSTLREDHQEPGSPHIATPNPQRVSNSATPVAQLLLPKSHSWGIVLPLGELEGKRSTRDRRSPAELEGGSASEGAARPVARFNSIPLTDTGHVEQHEGSSDPQIPESVFHLLVPGIILVLLTVGGLLFYKWKWRSHRDPQTLDSSVGRPEDSSLTQDEDRQVELPV
  
Inhibitor
Name:
BDBM97735
Synonyms:
US8481564, 12
Type:
Small organic molecule
Emp. Form.:
C22H22N8O
Mol. Mass.:
414.4631
SMILES:
O=C(Nc1ccc(cc1C1=CCCCC1)C1CNC(NC1)=NC#N)c1nc(c[nH]1)C#N |t:10,(6.88,1.32,;5.55,.55,;4.22,1.32,;2.88,.55,;2.88,-.99,;1.55,-1.76,;.22,-.99,;.22,.55,;1.55,1.32,;1.55,2.86,;2.88,3.63,;2.88,5.17,;1.55,5.94,;.22,5.17,;.22,3.63,;-1.12,-1.76,;-1.12,-3.3,;-2.45,-4.07,;-3.78,-3.3,;-3.78,-1.76,;-2.45,-.99,;-5.12,-4.07,;-6.45,-3.3,;-7.79,-2.53,;6.32,-.78,;5.42,-2.03,;6.32,-3.27,;7.79,-2.8,;7.79,-1.26,;5.55,-4.61,;4.78,-5.94,)|
Structure:
Search PDB for entries with ligand similarity: