Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM98680
Substrate
n/a
Meas. Tech.
FRET Assay
IC50
0.3±0.0 nM
Citation
 Yokokawa, F; Ehara, T; Kawakami, S; Irie, O; Suzuki, M; Hitomi, Y; Toyao, A Organic compounds US Patent  US8497286 Publication Date 7/30/2013 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM98680
Synonyms:
US8497286, 156
Type:
Small organic molecule
Emp. Form.:
C29H46N4O4
Mol. Mass.:
514.6999
SMILES:
CCOC[C@@H](NC(=O)[C@@H]1CNC[C@@H](C1)C(=O)N(C1CC1)c1cc(OC)c(cn1)C(C)C)C1CCCCC1 |r|
Structure:
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