Reaction Details Report a problem with these data
Target
Kallikrein-7
Ligand
BDBM100045
Substrate
n/a
EC50
8284±n/a nM
Citation
 PubChem, PC Fluorescence Intensity-based biochemical primary high throughput dose response assay to identify activators of kallikrein-7 (K7) zymogen PubChem Bioassay (2013)[AID] 
Target
Name:
Kallikrein-7
Synonyms:
KLK7 | KLK7_HUMAN | Kallikrein 7 | Kallikrein-7 | PRSS6 | SCCE | Serine protease 6 | Stratum corneum chymotryptic enzyme | hK7 | hSCCE | kallikrein-7 isoform 1 preproprotein
Type:
PROTEIN
Mol. Mass.:
27535.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469257
Residue:
253
Sequence:
MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
  
Inhibitor
Name:
BDBM100045
Synonyms:
6,7-dimethoxy-2-methyl-2,3-dihydro-1-benzothiopyran-4-one | 6,7-dimethoxy-2-methyl-2,3-dihydro-4H-thiochromen-4-one | 6,7-dimethoxy-2-methyl-2,3-dihydrothiochromen-4-one | 6,7-dimethoxy-2-methyl-thiochroman-4-one | MLS000537057 | SMR000161416 | cid_4165166
Type:
Small organic molecule
Emp. Form.:
C12H14O3S
Mol. Mass.:
238.303
SMILES:
COc1cc2SC(C)CC(=O)c2cc1OC
Structure:
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