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Target
Kallikrein-7
Ligand
BDBM100062
Substrate
n/a
EC50
7785±n/a nM
Citation
 PubChem, PC Fluorescence Intensity-based biochemical primary high throughput dose response assay to identify activators of kallikrein-7 (K7) zymogen PubChem Bioassay (2013)[AID] 
Target
Name:
Kallikrein-7
Synonyms:
KLK7 | KLK7_HUMAN | Kallikrein 7 | Kallikrein-7 | PRSS6 | SCCE | Serine protease 6 | Stratum corneum chymotryptic enzyme | hK7 | hSCCE | kallikrein-7 isoform 1 preproprotein
Type:
PROTEIN
Mol. Mass.:
27535.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469257
Residue:
253
Sequence:
MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
  
Inhibitor
Name:
BDBM100062
Synonyms:
5-keto-8-methyl-N-(tetrahydrofurfuryl)-2-(tetrahydrofurfurylamino)dipyrido[1,2-pyrimidine-3-carboxamide | 8-methyl-5-oxidanylidene-N-(oxolan-2-ylmethyl)-2-(oxolan-2-ylmethylamino)dipyrido[1,2-pyrimidine-3-carboxamide | 8-methyl-5-oxo-N-(2-oxolanylmethyl)-2-(2-oxolanylmethylamino)-3-dipyrido[1,2-pyrimidinecarboxamide | 8-methyl-5-oxo-N-(oxolan-2-ylmethyl)-2-(oxolan-2-ylmethylamino)dipyrido[1,2-pyrimidine-3-carboxamide | MLS000718469 | SMR000290737 | cid_3162241
Type:
Small organic molecule
Emp. Form.:
C23H27N5O4
Mol. Mass.:
437.4916
SMILES:
Cc1ccc2nc3nc(NCC4CCCO4)c(cc3c(=O)n2c1)C(=O)NCC1CCCO1
Structure:
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