Reaction Details Report a problem with these data
Target
Kallikrein-7
Ligand
BDBM100146
Substrate
n/a
EC50
>7724±n/a nM
Citation
 PubChem, PC Fluorescence Intensity-based biochemical primary high throughput dose response assay to identify activators of kallikrein-7 (K7) zymogen PubChem Bioassay (2013)[AID] 
Target
Name:
Kallikrein-7
Synonyms:
KLK7 | KLK7_HUMAN | Kallikrein 7 | Kallikrein-7 | PRSS6 | SCCE | Serine protease 6 | Stratum corneum chymotryptic enzyme | hK7 | hSCCE | kallikrein-7 isoform 1 preproprotein
Type:
PROTEIN
Mol. Mass.:
27535.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469257
Residue:
253
Sequence:
MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
  
Inhibitor
Name:
BDBM100146
Synonyms:
1-[2-(4-butyl-2-keto-7-methyl-chromen-5-yl)oxyacetyl]isonipecotic acid | 1-[2-(4-butyl-7-methyl-2-oxidanylidene-chromen-5-yl)oxyethanoyl]piperidine-4-carboxylic acid | 1-[2-(4-butyl-7-methyl-2-oxochromen-5-yl)oxyacetyl]piperidine-4-carboxylic acid | 1-[2-[(4-butyl-7-methyl-2-oxo-1-benzopyran-5-yl)oxy]-1-oxoethyl]-4-piperidinecarboxylic acid | MLS001157888 | SMR000651316 | cid_1777995
Type:
Small organic molecule
Emp. Form.:
C22H27NO6
Mol. Mass.:
401.4529
SMILES:
CCCCc1cc(=O)oc2cc(C)cc(OCC(=O)N3CCC(CC3)C(O)=O)c12
Structure:
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