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Target
Kallikrein-7
Ligand
BDBM100162
Substrate
n/a
EC50
7451±n/a nM
Citation
 PubChem, PC Fluorescence Intensity-based biochemical primary high throughput dose response assay to identify activators of kallikrein-7 (K7) zymogen PubChem Bioassay (2013)[AID] 
Target
Name:
Kallikrein-7
Synonyms:
KLK7 | KLK7_HUMAN | Kallikrein 7 | Kallikrein-7 | PRSS6 | SCCE | Serine protease 6 | Stratum corneum chymotryptic enzyme | hK7 | hSCCE | kallikrein-7 isoform 1 preproprotein
Type:
PROTEIN
Mol. Mass.:
27535.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469257
Residue:
253
Sequence:
MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
  
Inhibitor
Name:
BDBM100162
Synonyms:
3-[(3R,4S)-4-ethyl-5-(4-fluorophenyl)-2-phenyl-2-pyrazoline-3-carbonyl]oxazolidin-2-one | 3-[(3R,4S)-4-ethyl-5-(4-fluorophenyl)-2-phenyl-3,4-dihydropyrazole-3-carbonyl]-1,3-oxazolidin-2-one | 3-[[(3R,4S)-4-ethyl-5-(4-fluorophenyl)-2-phenyl-3,4-dihydropyrazol-3-yl]-oxomethyl]-2-oxazolidinone | 3-[[(3R,4S)-4-ethyl-5-(4-fluorophenyl)-2-phenyl-3,4-dihydropyrazol-3-yl]carbonyl]-1,3-oxazolidin-2-one | MLS000518755 | SMR000327305 | cid_16060044
Type:
Small organic molecule
Emp. Form.:
C21H20FN3O3
Mol. Mass.:
381.4002
SMILES:
CC[C@H]1[C@@H](N(N=C1c1ccc(F)cc1)c1ccccc1)C(=O)N1CCOC1=O |c:5|
Structure:
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