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Target
Kallikrein-7
Ligand
BDBM100186
Substrate
n/a
EC50
8157±n/a nM
Citation
 PubChem, PC Fluorescence Intensity-based biochemical primary high throughput dose response assay to identify activators of kallikrein-7 (K7) zymogen PubChem Bioassay (2013)[AID] 
Target
Name:
Kallikrein-7
Synonyms:
KLK7 | KLK7_HUMAN | Kallikrein 7 | Kallikrein-7 | PRSS6 | SCCE | Serine protease 6 | Stratum corneum chymotryptic enzyme | hK7 | hSCCE | kallikrein-7 isoform 1 preproprotein
Type:
PROTEIN
Mol. Mass.:
27535.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469257
Residue:
253
Sequence:
MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
  
Inhibitor
Name:
BDBM100186
Synonyms:
(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-N-[5-(dimethylamino)naphthalen-1-yl]sulfonyl-3,4-bis(oxidanyl)oxolane-2-carboxamide | (2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-N-[5-(dimethylamino)naphthalen-1-yl]sulfonyl-3,4-dihydroxyoxolane-2-carboxamide | (2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-N-[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]-3,4-dihydroxy-2-oxolanecarboxamide | (2S,3S,4R,5R)-5-adenin-9-yl-3,4-dihydroxy-N-naphthionyl-tetrahydrofuran-2-carboxamide | MLS003271259 | SMR001950854 | cid_51360273
Type:
Small organic molecule
Emp. Form.:
C22H23N7O6S
Mol. Mass.:
513.526
SMILES:
CN(C)c1cccc2c(cccc12)S(=O)(=O)NC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Structure:
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