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Target
Kallikrein-7
Ligand
BDBM100189
Substrate
n/a
EC50
>7722±n/a nM
Citation
 PubChem, PC Fluorescence Intensity-based biochemical primary high throughput dose response assay to identify activators of kallikrein-7 (K7) zymogen PubChem Bioassay (2013)[AID] 
Target
Name:
Kallikrein-7
Synonyms:
KLK7 | KLK7_HUMAN | Kallikrein 7 | Kallikrein-7 | PRSS6 | SCCE | Serine protease 6 | Stratum corneum chymotryptic enzyme | hK7 | hSCCE | kallikrein-7 isoform 1 preproprotein
Type:
PROTEIN
Mol. Mass.:
27535.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469257
Residue:
253
Sequence:
MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
  
Inhibitor
Name:
BDBM100189
Synonyms:
4-[7-(4-carbamoylphenyl)-1-(2-cyclopropyl-2-keto-ethyl)-3-(3,5-dimethoxyphenyl)-1H-isoquinolin-2-yl]benzoic acid methyl ester | 4-[7-(4-carbamoylphenyl)-1-(2-cyclopropyl-2-oxoethyl)-3-(3,5-dimethoxyphenyl)-1H-isoquinolin-2-yl]benzoic acid methyl ester | MLS003591678 | SMR002252975 | cid_53301491 | methyl 4-[7-(4-aminocarbonylphenyl)-1-(2-cyclopropyl-2-oxidanylidene-ethyl)-3-(3,5-dimethoxyphenyl)-1H-isoquinolin-2-yl]benzoate | methyl 4-[7-(4-carbamoylphenyl)-1-(2-cyclopropyl-2-oxoethyl)-3-(3,5-dimethoxyphenyl)-1H-isoquinolin-2-yl]benzoate
Type:
Small organic molecule
Emp. Form.:
C37H34N2O6
Mol. Mass.:
602.6757
SMILES:
COC(=O)c1ccc(cc1)N1C(CC(=O)C2CC2)c2cc(ccc2C=C1c1cc(OC)cc(OC)c1)-c1ccc(cc1)C(N)=O |c:27|
Structure:
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