Reaction Details Report a problem with these data
Target
COUP transcription factor 2
Ligand
BDBM100235
Substrate
n/a
IC50
5243±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay to identify inhibitors of COUP-TFII (NR2F2) PubChem Bioassay (2013)[AID] 
Target
Name:
COUP transcription factor 2
Synonyms:
ARP1 | COT2_HUMAN | COUP transcription factor 2 isoform a | NR2F2 | TFCOUP2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45583.83
Organism:
Homo sapiens (Human)
Description:
gi_14149746
Residue:
414
Sequence:
MAMVVSTWRDPQDEVPGSQGSQASQAPPVPGPPPGAPHTPQTPGQGGPASTPAQTAAGGQGGPGGPGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMAIQ
  
Inhibitor
Name:
BDBM100235
Synonyms:
1-[[2,7-bis(2-morpholin-4-ylethoxy)fluoren-9-ylidene]amino]thiourea | 2,7-bis(2-morpholin-4-ylethoxy)-9H-fluoren-9-one thiosemicarbazone | MLS001195079 | SMR000554482 | [[2,7-bis(2-morpholin-4-ylethoxy)fluoren-9-ylidene]amino]thiourea | [[2,7-bis(2-morpholinoethoxy)fluoren-9-ylidene]amino]thiourea | [[2,7-bis[2-(4-morpholinyl)ethoxy]-9-fluorenylidene]amino]thiourea | cid_4551824
Type:
Small organic molecule
Emp. Form.:
C26H33N5O4S
Mol. Mass.:
511.636
SMILES:
[#7]-[#6](=S)-[#7]\[#7]=[#6]-1/c2cc(-[#8]-[#6]-[#6]-[#7]-3-[#6]-[#6]-[#8]-[#6]-[#6]-3)ccc2-c2ccc(-[#8]-[#6]-[#6]-[#7]-3-[#6]-[#6]-[#8]-[#6]-[#6]-3)cc-12
Structure:
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