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Target
C-C chemokine receptor type 1
Ligand
BDBM102327
Substrate
n/a
Meas. Tech.
Scintillation Proximity Assay (SPA)
IC50
1.0±0.0 nM
Citation
 Santella, JB; Hynes, J; Gardner, DS Piperidine derivatives as modulators of chemokine receptor activity US Patent  US8536198 Publication Date 9/17/2013 
Target
Name:
C-C chemokine receptor type 1
Synonyms:
C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1
Type:
Enzyme
Mol. Mass.:
41180.69
Organism:
Homo sapiens (Human)
Description:
P32246
Residue:
355
Sequence:
METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
  
Inhibitor
Name:
BDBM102327
Synonyms:
US8536198, 80
Type:
Small organic molecule
Emp. Form.:
C26H32ClN3O5S
Mol. Mass.:
534.067
SMILES:
CC1(C)CN(CC[C@]1(O)c1ccc(Cl)cc1)C(=O)[C@H]1CCC[C@H]1NC(=O)c1cccc(c1)S(N)(=O)=O |r|
Structure:
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