Reaction Details Report a problem with these data
Target
Peptidase 1
Ligand
BDBM103020
Substrate
n/a
Meas. Tech.
Enzyme Activity Assay
IC50
14±0.0 nM
Citation
 Robinson, C; Zhang, J; Garrod, DR; Perrior, TR; Newton, GK; Jenkins, K; Beevers, RE; Major, MR; Stewart, MR Pyruvamide compounds as inhibitors of dust mite group 1 peptidase allergen and their use US Patent  US8541363 Publication Date 9/24/2013 
Target
Name:
Peptidase 1
Synonyms:
DERP1 | PEPT1_DERPT | Peptidase 1 (Der p 1)
Type:
Enzyme
Mol. Mass.:
36101.04
Organism:
Dermatophagoides pteronyssinus (European house dust mite)
Description:
P08176
Residue:
320
Sequence:
MKIVLAIASLLALSAVYARPSSIKTFEEYKKAFNKSYATFEDEEAARKNFLESVKYVQSNGGAINHLSDLSLDEFKNRFLMSAEAFEHLKTQFDLNAETNACSINGNAPAEIDLRQMRTVTPIRMQGGCGSCWAFSGVAATESAYLAYRNQSLDLAEQELVDCASQHGCHGDTIPRGIEYIQHNGVVQESYYRYVAREQSCRRPNAQRFGISNYCQIYPPNVNKIREALAQTHSAIAVIIGIKDLDAFRHYDGRTIIQRDNGYQPNYHAVNIVGYSNAQGVDYWIVRNSWDTNWGDNGYGYFAANIDLMMIEEYPYVVIL
  
Inhibitor
Name:
BDBM103020
Synonyms:
US8541363, PVA-026
Type:
Small organic molecule
Emp. Form.:
C28H42N4O5
Mol. Mass.:
514.6569
SMILES:
CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(C)(C)C)C(=O)C(=O)NC1CCCCC1 |r|
Structure:
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