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Target
Protein mono-ADP-ribosyltransferase PARP3 [R100H]
Ligand
BDBM103554
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
6.0e+3± 2.2e+3 nM
Citation
 Lindgren, AE; Karlberg, T; Thorsell, AG; Hesse, M; Spjut, S; Ekblad, T; Andersson, CD; Pinto, AF; Weigelt, J; Hottiger, MO; Linusson, A; Elofsson, M; Schüler, H PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3. ACS Chem Biol 8:1698-703 (2013) [PubMed]  Article 
Target
Name:
Protein mono-ADP-ribosyltransferase PARP3 [R100H]
Synonyms:
(ARTD3 or PARP3) | ADP-ribosyltransferase diphtheria toxin-like 3 | ADPRT3 | ADPRTL3 | Human diphtheria toxin-like ADP-ribosyltransferase (ARTD3 or PARP3) | PARP3 | PARP3_HUMAN | Poly [ADP-ribose] polymerase 3 | Poly [ADP-ribose] polymerase 3 (PARP-3) | Poly(ADP-ribose) polymerase-3 (ARTD3/PARP3)
Type:
PROTEIN
Mol. Mass.:
60071.85
Organism:
Homo sapiens (Human)
Description:
Q9Y6F1[R100H]
Residue:
533
Sequence:
MAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCPLSSNPGTQVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNHWGRVGEVGQSKINHFTRLEDAKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTKRVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEALKGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCPTLQHIWKVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPTQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
  
Inhibitor
Name:
BDBM103554
Synonyms:
STO1131 | US8551988, 39
Type:
Small organic molecule
Emp. Form.:
C18H18N4O2
Mol. Mass.:
322.3611
SMILES:
CC(NC(=O)CCc1nc2ccccc2c(=O)[nH]1)c1ccccn1
Structure:
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