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Target
Serine/threonine-protein kinase PKH2 [1-944]
Ligand
BDBM104016
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
pH
7.4±n/a
EC50
4.4e+4±n/a nM
Comments
extracted
Citation
 Pastor-Flores, D; Schulze, JO; Bahí, A; Bahí, R; Ferrer-Dalmau, J; Passeron, S; Engel, M; Süss, E; Süss, A; Biondi, RM PIF-pocket as a target for C. albicans Pkh selective inhibitors. ACS Chem Biol 8:2283-92 (2013) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase PKH2 [1-944]
Synonyms:
Likely protein kinase | PKH1 | PKH2 | PKH2_CANAL | Serine/threonine-protein kinase 2 (CaPkh2)
Type:
Protein
Mol. Mass.:
106226.24
Organism:
Candida albicans SC5314
Description:
Q5A3P6[1-944]
Residue:
944
Sequence:
MHKFRYSLHQHYSKRNSSDKSKDSPISQNSNEENDSTKLSSSSLQDLHDDLDDIYNNYTLAQGTNNNSVDTLDSENNQAINKFIDKPPAIHGMEPQLPVMHVSSRLSSLGNTTNETGESIAKSAPGTPLSSHSFDFRPHHPRAVTNSSLNVLLDTPNVSSEFNHLVDQTPPNESVERFDDSNNTVDNTEEEENNDDTDEIPKSETLKQNEENWEKKGAAVKTIKTMDGEMKTIRRNVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIKYMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVSPELLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKLQFAFSAGFPTIIRDLIKKILVLQPSRRATIPEIQKHYFFQSVDFKDFDSIWLSDPPEIGPYKMTAKSMMKVPELNKAPITTVIKKNVKKSTNSNSNTNNVATAVGGSSSNGHKGSSPTPEKEPSPATINNKSTEKVSAASVAAYVLNKPATNQNSSTSEDSSKRSSNSNETRKLSYSQQDYIPGTNILRPQISTRPSVGSYVKTTPSKDRKTLTKVPSNIHQQQEKVKPKVMEVKPATTLEAAWEPYLTHPDERILRIGPVIAHKEPTEPFEKKNKASLHISPLDINKEQRSRSNTSLLTQIVNEVNNNTSELKKVENADESLAIIEPQYNMKRSPTSDSKKSMDIERSASTSGSRISKKAIFKKLGFSHLEKNDSEESNGPSLTEKPQTCTLVVTTHGRALLFIRNDIESNYLLIAEIKLKYPFIHFQELVISQTKFSKLVPSVGVFVISSIDNSLIFEVEKFEVNQWTEALAKSKYNEI
  
Inhibitor
Name:
BDBM104016
Synonyms:
PS77
Type:
Small organic molecule
Emp. Form.:
C23H18Cl2O3S2
Mol. Mass.:
477.423
SMILES:
OC(=O)CSC(CC(=O)c1ccc(Cl)cc1)c1ccccc1Sc1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: