Reaction Details Report a problem with these data
Target
DNA polymerase beta
Ligand
BDBM104074
Substrate
n/a
Meas. Tech.
DNA Pol β PEX Assay
pH
7.9±n/a
IC50
<5.0e+4±n/a nM
Comments
extracted
Citation
 Strittmatter, T; Brockmann, A; Pott, M; Hantusch, A; Brunner, T; Marx, A Expanding the Scope of Human DNA Polymerase ¿ and ß Inhibitors. ACS Chem Biol 9:282-90 (2014) [PubMed]  Article 
Target
Name:
DNA polymerase beta
Synonyms:
DNA polymerase beta (Pol β) | DPOLB_HUMAN | POLB
Type:
Protein
Mol. Mass.:
38188.76
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
335
Sequence:
MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
  
Inhibitor
Name:
BDBM104074
Synonyms:
(Z)-5-(1-(3-Nitro-4-(p-tolylthio)phenyl)ethylidene)-2- thioxothiazolidin-4-one 8 | DNA polymerase inhibitor 8
Type:
Small organic molecule
Emp. Form.:
C18H14N2O3S3
Mol. Mass.:
402.51
SMILES:
Cc1ccc(Sc2ccc(cc2[N+]([O-])=O)C(=C)c2sc(S)nc2O)cc1
Structure:
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