Reaction Details Report a problem with these data
Target
DNA polymerase beta
Ligand
BDBM104085
Substrate
n/a
Meas. Tech.
DNA Pol β PEX Assay
pH
7.9±n/a
IC50
>5.0e+4±n/a nM
Comments
extracted
Citation
 Strittmatter, T; Brockmann, A; Pott, M; Hantusch, A; Brunner, T; Marx, A Expanding the Scope of Human DNA Polymerase ¿ and ß Inhibitors. ACS Chem Biol 9:282-90 (2014) [PubMed]  Article 
Target
Name:
DNA polymerase beta
Synonyms:
DNA polymerase beta (Pol β) | DPOLB_HUMAN | POLB
Type:
Protein
Mol. Mass.:
38188.76
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
335
Sequence:
MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
  
Inhibitor
Name:
BDBM104085
Synonyms:
(Z)-5-(3-Nitro-4-((4-(trifluoromethoxy)phenyl)thio)benzylidene)-2- thioxothiazolidin-4-one 19 | DNA polymerase inhibitor 19
Type:
Small organic molecule
Emp. Form.:
C17H9F3N2O4S3
Mol. Mass.:
458.455
SMILES:
[O-][N+](=O)c1cc(C=C2SC(S)=NC2=O)ccc1Sc1ccc(OC(F)(F)F)cc1 |w:6.5,c:10|
Structure:
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