Reaction Details Report a problem with these data
Target
DNA polymerase beta
Ligand
BDBM104090
Substrate
n/a
Meas. Tech.
DNA Pol β PEX Assay
pH
7.9±n/a
IC50
<5.0e+4±n/a nM
Comments
extracted
Citation
 Strittmatter, T; Brockmann, A; Pott, M; Hantusch, A; Brunner, T; Marx, A Expanding the Scope of Human DNA Polymerase ¿ and ß Inhibitors. ACS Chem Biol 9:282-90 (2014) [PubMed]  Article 
Target
Name:
DNA polymerase beta
Synonyms:
DNA polymerase beta (Pol β) | DPOLB_HUMAN | POLB
Type:
Protein
Mol. Mass.:
38188.76
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
335
Sequence:
MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
  
Inhibitor
Name:
BDBM104090
Synonyms:
(Z)-5-(4-((3,5-Dimethylphenyl)thio)-3-nitrobenzylidene)-2- thioxothiazolidin-4-one 24 | DNA polymerase inhibitor 24
Type:
Small organic molecule
Emp. Form.:
C18H14N2O3S3
Mol. Mass.:
402.51
SMILES:
Cc1cc(C)cc(Sc2ccc(C=C3SC(S)=NC3=O)cc2[N+]([O-])=O)c1 |w:12.11,c:16|
Structure:
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