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Target
Cyclin-dependent kinase 2
Ligand
BDBM105239
Substrate
n/a
Meas. Tech.
In Vitro Kinase Assay
pH
8±0
IC50
6±n/a nM
Citation
 Guzi, TJ; Paruch, K; Dwyer, MP; Labroli, MA; Keertikar, KM Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors US Patent  US8580782 Publication Date 11/12/2013 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM105239
Synonyms:
US8580782, 7
Type:
Small organic molecule
Emp. Form.:
C18H13BrClN5
Mol. Mass.:
414.686
SMILES:
Clc1ccccc1-c1cc(NCc2ccncc2)n2ncc(Br)c2n1
Structure:
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