Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Probable G-protein coupled receptor 160
Ligand
BDBM281726
Substrate
n/a
Meas. Tech.
GPR120 pERK AlphaScreen SureFire Assay
Temperature
298.15±n/a K
EC50
330±n/a nM
Comments
extracted
Citation
Shi, Y; Wang, Y; Cheng, PT; Wu, SC Cyclobutane containing carboxylic acid GPR120 modulators US Patent US10023519 Publication Date 7/17/2018 More Info.:
Target
Name:
Probable G-protein coupled receptor 160
Synonyms:
G-protein coupled receptor GPCR1 | GP160_HUMAN | GPCR150 | GPR160 | hGPCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39797.81
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
338
Sequence:
MTALSSENCSFQYQLRQTNQPLDVNYLLFLIILGKILLNILTLGMRRKNTCQNFMEYFCISLAFVDLLLLVNISIILYFRDFVLLSIRFTKYHICLFTQIISFTYGFLHYPVFLTACIDYCLNFSKTTKLSFKCQKLFYFFTVILIWISVLAYVLGDPAIYQSLKAQNAYSRHCPFYVSIQSYWLSFFMVMILFVAFITCWEEVTTLVQAIRITSYMNETILYFPFSSHSSYTVRSKKIFLSKLIVCFLSTWLPFVLLQVIIVLLKVQIPAYIEMNIPWLYFVNSFLIATVYWFNCHKLNLKDIGLPLDPFVNWKCCFIPLTIPNLEQIEKPISIMIC
Inhibitor
Name:
BDBM281726
Synonyms:
Cis-2-(3-((2′-fluoro-5′-phenoxy-[1,1′-biphenyl]-4-yl)oxy)cyclobutyl)acetic acid | US10023519, Example 67
Type:
Small organic molecule
Emp. Form.:
C24H21FO4
Mol. Mass.:
392.4195
SMILES:
OC(=O)C[C@H]1C[C@H](C1)Oc1ccc(cc1)-c1cc(Oc2ccccc2)ccc1F |r,wU:6.8,4.3,(8.95,2.38,;7.61,3.15,;7.61,4.69,;6.28,2.38,;4.94,3.15,;3.46,2.75,;3.06,4.23,;4.55,4.63,;1.72,5,;.39,4.23,;-.94,5,;-2.28,4.23,;-2.28,2.69,;-.94,1.93,;.39,2.69,;-3.61,1.93,;-3.61,.38,;-4.94,-.38,;-4.94,-1.93,;-6.28,-2.69,;-7.61,-1.93,;-8.95,-2.69,;-8.95,-4.23,;-7.61,-5,;-6.28,-4.23,;-6.28,.38,;-6.28,1.93,;-4.94,2.69,;-4.94,4.23,)|
Structure:
