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Target
Egl nine homolog 1
Ligand
BDBM107710
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
2.5e+3±n/a nM
Citation
 Kawamoto, RM; Wu, S; Warshakoon, NC; Evdokimov, AG; Greis, KD; Boyer, AS Prolyl hydroxylase inhibitors and methods of use US Patent  US8598210 Publication Date 12/3/2013 
Target
Name:
Egl nine homolog 1
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:
Protein
Mol. Mass.:
46035.59
Organism:
Homo sapiens (Human)
Description:
Q9GZT9
Residue:
426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM107710
Synonyms:
US11426393, Compound Table XV.16 | US8598210, Table XV, 16 | US8722895, 16: {[5-(2-Methyl-5-chlorophenyl)-3- hydroxypyridine-2-carbonyl]amino}-acetic acid | US9598370, Example 00141 | USRE47437, Example {[5-(2-Methyl-5-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}-aceticacid
Type:
Small organic molecule
Emp. Form.:
C15H13ClN2O4
Mol. Mass.:
320.728
SMILES:
Cc1ccc(Cl)cc1-c1cnc(C(=O)NCC(O)=O)c(O)c1
Structure:
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