Reaction Details Report a problem with these data
Target
Receptor protein-tyrosine kinase
Ligand
BDBM108059
Substrate
n/a
Meas. Tech.
Z-LYTE biochemical assay
Temperature
298.15±n/a K
IC50
1.37e+3±n/a nM
Comments
extracted
Citation
 Jia, Y; Zhang, J; Feng, J; Xu, F; Pan, H; Xu, W Design, synthesis and biological evaluation of pazopanib derivatives as antitumor agents. Chem Biol Drug Des 83:306-16 (2014) [PubMed]  Article 
Target
Name:
Receptor protein-tyrosine kinase
Synonyms:
EGFR | Q504U8_HUMAN
Type:
Protein
Mol. Mass.:
120695.83
Organism:
Homo sapiens (Human)
Description:
Q504U8
Residue:
1091
Sequence:
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQGQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPGEWLVWKQSCSSTSSTHSAAASLQCPSQVLPPASPEGETVADLQTQ
  
Inhibitor
Name:
BDBM108059
Synonyms:
N-carbamimidoyl-4-((4-((2,3-dimethyl-2H-indazole- 6-yl)(methyl)amino)pyrimidin-2-yl)amino) benzenesulfonamide (P2g)
Type:
Small organic molecule
Emp. Form.:
C21H23N9O2S
Mol. Mass.:
465.531
SMILES:
CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(cc2)S(=O)(=O)NC(N)=N)n1
Structure:
Search PDB for entries with ligand similarity: