Reaction Details Report a problem with these data
Target
Cell surface glycoprotein MUC18
Ligand
BDBM111114
Substrate
n/a
Meas. Tech.
Mushroom Tyrosinase Assay
Temperature
298.15±n/a K
IC50
4500±n/a nM
Comments
extracted
Citation
 Nandy, SK; Liu, J; Nesterov, AM; Hertel, C; Papmapiya, AA Series of skin-whitening (lightening) compounds US Patent  US9682910 Publication Date 6/20/2017 
Target
Name:
Cell surface glycoprotein MUC18
Synonyms:
Gicerin | MUC18_MOUSE | Mcam | Melanoma cell adhesion molecule | Melanoma-associated antigen MUC18 | Muc18
Type:
Protein
Mol. Mass.:
71536.56
Organism:
Mouse
Description:
Q8R2Y2
Residue:
648
Sequence:
MGLPKLVCVFLFAACCCCRRAAGVPGEEKQPVPTPDLVEAEVGSTALLKCGPSRASGNFSQVDWFLIHKERQILIFRVHQGKGQREPGEYEHRLSLQDSVATLALSHVTPHDERMFLCKSKRPRLQDHYVELQVFKAPEEPTIQANVVGIHVDRQELREVATCVGRNGYPIPQVLWYKNSLPLQEEENRVHIQSSQIVESSGLYTLKSVLSARLVKEDKDAQFYCELSYRLPSGNHMKESKEVTVPVFYPAEKVWVEVEPVGLLKEGDHVTIRCLTDGNPQPHFTINKKDPSTGEMEEESTDENGLLSLEPAEKHHSGLYQCQSLDLETTITLSSDPLELLVNYVSDVQVNPTAPEVQEGESLTLTCEAESNQDLEFEWLRDKTGQLLGKGPVLQLNNVRREAGGRYLCMASVPRVPGLNRTQLVSVGIFGSPWMALKERKVWVQENAVLNLSCEASGHPQPTISWNVNGSATEWNPDPQTVVSTLNVLVTPELLETGAECTASNSLGSNTTTIVLKLVTLTTLIPDSSQTTGLSTLTVSPHTRANSTSTEKKLPQPESKGVVIVAVIVCTLVLAVLGAALYFFYKKGKLPCGRSGKQEITLPPTRKSEFVVEVKSDKLPEEMALLQGSNGDKRAPGDQGEKYIDLRH
  
Inhibitor
Name:
BDBM111114
Synonyms:
US9682910, 4-(2-(tetrahydrofuran-2-yl)ethyl)benzene-1,3-diol (25)
Type:
Small organic molecule
Emp. Form.:
C12H16O3
Mol. Mass.:
208.2536
SMILES:
Oc1ccc(CCC2CCCO2)c(O)c1
Structure:
Search PDB for entries with ligand similarity: