Reaction Details Report a problem with these data
Target
Carboxypeptidase B2
Ligand
BDBM109258
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
5.4±n/a nM
Citation
 Nagata, T; Inoue, M; Ashida, Y; Noguchi, K; Ono, M Cycloalkyl-substituted imidazole derivative US Patent  US8609710 Publication Date 12/17/2013 
Target
Name:
Carboxypeptidase B2
Synonyms:
CBPB2_HUMAN | CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB
Type:
Enzyme
Mol. Mass.:
48432.74
Organism:
Homo sapiens (Human)
Description:
Q96IY4
Residue:
423
Sequence:
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTADLIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYYEQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGIHAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRKNRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSETLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVIRNV
  
Inhibitor
Name:
BDBM109258
Synonyms:
US8609710, 34 (2S,4S form)
Type:
Small organic molecule
Emp. Form.:
C17H29N3O2
Mol. Mass.:
307.4311
SMILES:
C[C@H](CN)C[C@@H](Cc1cn(cn1)[C@H]1CC[C@H](C)CC1)C(O)=O |r,wU:12.12,1.0,wD:5.5,15.16,(4.54,-1.29,;3.21,-.52,;3.21,1.02,;4.54,1.79,;1.87,-1.29,;1.87,-2.83,;.54,-3.6,;-.79,-2.83,;-.79,-1.29,;-2.26,-.81,;-3.16,-2.06,;-2.26,-3.3,;-2.66,.68,;-4.14,1.07,;-4.54,2.56,;-3.45,3.65,;-3.85,5.14,;-1.97,3.25,;-1.57,1.76,;3.21,-3.6,;3.21,-5.14,;4.54,-2.83,)|
Structure:
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