Reaction Details Report a problem with these data
Target
Carboxypeptidase B2
Ligand
BDBM109264
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
2.6±n/a nM
Citation
 Nagata, T; Inoue, M; Ashida, Y; Noguchi, K; Ono, M Cycloalkyl-substituted imidazole derivative US Patent  US8609710 Publication Date 12/17/2013 
Target
Name:
Carboxypeptidase B2
Synonyms:
CBPB2_HUMAN | CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB
Type:
Enzyme
Mol. Mass.:
48432.74
Organism:
Homo sapiens (Human)
Description:
Q96IY4
Residue:
423
Sequence:
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTADLIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYYEQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGIHAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRKNRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSETLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVIRNV
  
Inhibitor
Name:
BDBM109264
Synonyms:
US8609710, 40
Type:
Small organic molecule
Emp. Form.:
C16H27N3O2
Mol. Mass.:
293.4045
SMILES:
C[C@H]1CC[C@@H](CC1)n1cnc(C[C@H](CCCN)C(O)=O)c1 |r,wU:4.7,wD:1.0,12.12,(-6.38,5.14,;-5.98,3.65,;-7.07,2.56,;-6.67,1.07,;-5.18,.68,;-4.09,1.76,;-4.49,3.25,;-4.78,-.81,;-5.69,-2.06,;-4.78,-3.3,;-3.32,-2.83,;-1.98,-3.6,;-.65,-2.83,;-.65,-1.29,;.68,-.52,;.68,1.02,;2.02,1.79,;.68,-3.6,;2.02,-2.83,;.68,-5.14,;-3.32,-1.29,)|
Structure:
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