Reaction Details Report a problem with these data
Target
Prostaglandin E synthase
Ligand
BDBM111818
Substrate
n/a
Meas. Tech.
Microsomal prostaglandin E synthase-1 activity assay
pH
7±n/a
Temperature
293.15±n/a K
IC50
2.027e+4± 2.11e+3 nM
Comments
extracted
Citation
 Ahmad, W; Kumolosasi, E; Jantan, I; Bukhari, SN; Jasamai, M Effects of novel diarylpentanoid analogues of curcumin on secretory phospholipase A2 , cyclooxygenases, lipo-oxygenase, and microsomal prostaglandin E synthase-1. Chem Biol Drug Des 83:670-81 (2014) [PubMed]  Article 
Target
Name:
Prostaglandin E synthase
Synonyms:
MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1)
Type:
Protein
Mol. Mass.:
17112.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
152
Sequence:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL
  
Inhibitor
Name:
BDBM111818
Synonyms:
(2E,6E)‐2,6‐bis(2‐phenylpropylidene)cyclohexan‐1‐ one (4)
Type:
Small organic molecule
Emp. Form.:
C24H26O
Mol. Mass.:
330.4626
SMILES:
CC(C=C1CCCC(=CC(C)c2ccccc2)C1=O)c1ccccc1 |w:2.1,8.8|
Structure:
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