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Target
Prostaglandin E synthase
Ligand
BDBM50265039
Substrate
n/a
Meas. Tech.
Microsomal prostaglandin E synthase-1 activity assay
pH
7±n/a
Temperature
293.15±n/a K
IC50
3.699e+4± 4.32e+3 nM
Comments
extracted
Citation
 Ahmad, W; Kumolosasi, E; Jantan, I; Bukhari, SN; Jasamai, M Effects of novel diarylpentanoid analogues of curcumin on secretory phospholipase A2 , cyclooxygenases, lipo-oxygenase, and microsomal prostaglandin E synthase-1. Chem Biol Drug Des 83:670-81 (2014) [PubMed]  Article 
Target
Name:
Prostaglandin E synthase
Synonyms:
MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1)
Type:
Protein
Mol. Mass.:
17112.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
152
Sequence:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL
  
Inhibitor
Name:
BDBM50265039
Synonyms:
(1E,4E)‐1,5‐bis(4‐tert‐butylphenyl)penta‐1,4‐dien‐3‐ one (8) | (1E,4E)-1,5-Bis(4-tert-butylphenyl)penta-1,4-dien-3-one | 1,5-bis(4-tert-butylphenyl)penta-1,4-dien-3-one | CHEMBL498590
Type:
Small organic molecule
Emp. Form.:
C25H30O
Mol. Mass.:
346.5051
SMILES:
CC(C)(C)c1ccc(\C=C\C(=O)\C=C\c2ccc(cc2)C(C)(C)C)cc1
Structure:
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