Reaction Details Report a problem with these data
Target
Cystathionine gamma-lyase
Ligand
BDBM112639
Substrate
n/a
Meas. Tech.
Human CSE enzyme assay
pH
7±n/a
Temperature
310.15±n/a K
IC50
>2.00e+5±n/a nM
Comments
extracted
Citation
 Ren, J; Zhang, Y; Jin, H; Yu, J; Zhou, Y; Wu, F; Zhang, W Novel inhibitors of human DOPA decarboxylase extracted from Euonymus glabra Roxb. ACS Chem Biol 9:897-903 (2014) [PubMed]  Article 
Target
Name:
Cystathionine gamma-lyase
Synonyms:
CGL_HUMAN | CTH | Cystathionine gamma-lyase (CSE) | Cysteine-protein sulfhydrase | Gamma-cystathionase
Type:
Protein
Mol. Mass.:
44509.52
Organism:
Homo sapiens (Human)
Description:
P32929
Residue:
405
Sequence:
MQEKDASSQGFLPHFQHFATQAIHVGQDPEQWTSRAVVPPISLSTTFKQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKHGDIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAAHPPSGSHS
  
Inhibitor
Name:
BDBM112639
Synonyms:
1-(2-hydroxy-4-meth-oxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)propane (12)
Type:
Small organic molecule
Emp. Form.:
C17H20O4
Mol. Mass.:
288.3383
SMILES:
COc1ccc(CCCc2ccc(O)c(OC)c2)c(O)c1
Structure:
Search PDB for entries with ligand similarity: