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Target
Alpha-glucosidase MAL12
Ligand
BDBM112652
Substrate
n/a
Meas. Tech.
Glucosidase assay
pH
6.8±n/a
Temperature
310.15±n/a K
IC50
1.2243e+5± 1.27e+3 nM
Comments
extracted
Citation
 Yar, M; Bajda, M; Shahzadi, L; Shahzad, SA; Ahmed, M; Ashraf, M; Alam, U; Khan, IU; Khan, AF Novel synthesis of dihydropyrimidines for a-glucosidase inhibition to treat type 2 diabetes: in vitro biological evaluation and in silico docking. Bioorg Chem 54:96-104 (2014) [PubMed]  Article 
Target
Name:
Alpha-glucosidase MAL12
Synonyms:
α-Glucosidase | MAL12 | MAL12_YEAST | MAL1S | Maltase | alpha-Glucosidase (α-Glucosidase)
Type:
Protein
Mol. Mass.:
68084.32
Organism:
Saccharomyces cerevisiae
Description:
P53341
Residue:
584
Sequence:
MTISDHPETEPKWWKEATIYQIYPASFKDSNNDGWGDLKGITSKLQYIKDLGVDAIWVCPFYDSPQQDMGYDISNYEKVWPTYGTNEDCFELIDKTHKLGMKFITDLVINHCSTEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSFFGGSAWTFDETTNEFYLRLFASRQVDLNWENEDCRRAIFESAVGFWLDHGVDGFRIDTAGLYSKRPGLPDSPIFDKTSKLQHPNWGSHNGPRIHEYHQELHRFMKNRVKDGREIMTVGEVAHGSDNALYTSAARYEVSEVFSFTHVEVGTSPFFRYNIVPFTLKQWKEAIASNFLFINGTDSWATTYIENHDQARSITRFADDSPKYRKISGKLLTLLECSLTGTLYVYQGQEIGQINFKEWPIEKYEDVDVKNNYEIIKKSFGKNSKEMKDFFKGIALLSRDHSRTPMPWTKDKPNAGFTGPDVKPWFLLNESFEQGINVEQESRDDDSVLNFWKRALQARKKYKELMIYGYDFQFIDLDSDQIFSFTKEYEDKTLFAALNFSGEEIEFSLPREGASLSFILGNYDDTDVSSRVLKPWEGRIYLVK
  
Inhibitor
Name:
BDBM112652
Synonyms:
(±)2,6-Methano-4-oxo-3,4,5,6-tetrahydro-2H- [1,3,5]benzoxadiazocines (4d)
Type:
Small organic molecule
Emp. Form.:
C14H16N2O4
Mol. Mass.:
276.2878
SMILES:
CCOC(=O)[C@H]1[C@@H]2NC(=O)NC1(C)Oc1ccccc21 |r,TLB:9:8:5:19.14.13|
Structure:
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