Reaction Details Report a problem with these data
Target
Major prion protein
Ligand
BDBM114404
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
9735±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM114404
Synonyms:
MLS001029990 | SMR000427193 | [2-cyano-2-(5-cyano-2-hydroxy-2-phenyl-3-pyridin-1-ium-1-yl-4-thiophen-2-yl-3,4-dihydro-1H-pyridin-6-yl)ethenylidene]azanide | [2-cyano-2-(5-cyano-2-oxidanyl-2-phenyl-3-pyridin-1-ium-1-yl-4-thiophen-2-yl-3,4-dihydro-1H-pyridin-6-yl)ethenylidene]azanide | [2-cyano-2-[5-cyano-2-hydroxy-2-phenyl-3-(1-pyridin-1-iumyl)-4-thiophen-2-yl-3,4-dihydro-1H-pyridin-6-yl]ethenylidene]azanide | [2-cyano-2-[5-cyano-2-hydroxy-2-phenyl-3-pyridin-1-ium-1-yl-4-(2-thienyl)-3,4-dihydro-1H-pyridin-6-yl]ethenylidene]azanide | cid_3714754
Type:
Small organic molecule
Emp. Form.:
C24H17N5OS
Mol. Mass.:
423.49
SMILES:
OC1(N=C(C(C#N)C(C1[n+]1ccccc1)c1cccs1)[C-](C#N)C#N)c1ccccc1 |c:2|
Structure:
Search PDB for entries with ligand similarity: