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Target
Major prion protein
Ligand
BDBM66187
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
4555±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM66187
Synonyms:
5,5-Dimethyl-2-thioxo-2,3,5,6-tetrahydro-1H-benzo[h]quinazolin-4-one | 5,5-dimethyl-2-sulfanylidene-1,6-dihydrobenzo[h]quinazolin-4-one | 5,5-dimethyl-2-thioxo-1,6-dihydrobenzo[h]quinazolin-4-one | MLS001211957 | SMR000505168 | cid_713572
Type:
Small organic molecule
Emp. Form.:
C14H14N2OS
Mol. Mass.:
258.339
SMILES:
CC1(C)Cc2ccccc2-c2[nH]c(=S)[nH]c(=O)c12
Structure:
Search PDB for entries with ligand similarity: