Reaction Details Report a problem with these data
Target
Group 3 secretory phospholipase A2
Ligand
BDBM57726
Substrate
n/a
Meas. Tech.
QFRET-based biochemical high throughput dose response assay to identify inhibitors of human group III secreted phospholipase A2 enzyme (HGIII-sPLA2)
IC50
47320±n/a nM
Citation
 PubChem, PC QFRET-based biochemical high throughput dose response assay to identify inhibitors of human group III secreted phospholipase A2 enzyme (HGIII-sPLA2) PubChem Bioassay (2014)[AID] 
Target
Name:
Group 3 secretory phospholipase A2
Synonyms:
3.1.1.4 | GIII sPLA2 | Group III secretory phopholipase A2 | Group III secretory phospholipase A2 | PA2G3_HUMAN | PLA2G3 | Phosphatidylcholine 2-acylhydrolase 3 | phospholipase A2, group III | sPLA2-III
Type:
PROTEIN
Mol. Mass.:
57196.58
Organism:
Homo sapiens
Description:
ChEMBL_119722
Residue:
509
Sequence:
MGVQAGLFGMLGFLGVALGGSPALRWYRTSCHLTKAVPGNPLGYLSFLAKDAQGLALIHARWDAHRRLQSCSWEDEPELTAAYGALCAHETAWGSFIHTPGPELQRALATLQSQWEACRALEESPAGARKKRAAGQSGVPGGGHQREKRGWTMPGTLWCGVGDSAGNSSELGVFQGPDLCCREHDRCPQNISPLQYNYGIRNYRFHTISHCDCDTRFQQCLQNQHDSISDIVGVAFFNVLEIPCFVLEEQEACVAWYWWGGCRMYGTVPLARLQPRTFYNASWSSRATSPTPSSRSPAPPKPRQKQHLRKGPPHQKGSKRPSKANTTALQDPMVSPRLDVAPTGLQGPQGGLKPQGARWVCRSFRRHLDQCEHQIGPREIEFQLLNSAQEPLFHCNCTRRLARFLRLHSPPEVTNMLWELLGTTCFKLAPPLDCVEGKNCSRDPRAIRVSARHLRRLQQRRHQLQDKGTDERQPWPSEPLRGPMSFYNQCLQLTQAARRPDRQQKSWSQ
  
Inhibitor
Name:
BDBM57726
Synonyms:
(2Z)-2-(4-chlorophenyl)sulfonyl-2-(phenylhydrazono)acetohydrazide | 2-(4-chlorophenyl)sulfonyl-2-(phenylhydrazinylidene)acetohydrazide | 2-(4-chlorophenyl)sulfonyl-2-(phenylhydrazinylidene)ethanehydrazide | 2-(4-chlorophenyl)sulfonyl-2-(phenylhydrazono)acetohydrazide | 2-[(4-chlorophenyl)sulfonyl]-2-(phenylhydrazono)acetohydrazide | MLS000700702 | SMR000225122 | cid_1210927
Type:
Small organic molecule
Emp. Form.:
C14H13ClN4O3S
Mol. Mass.:
352.796
SMILES:
NNC(=O)C(=NNc1ccccc1)S(=O)(=O)c1ccc(Cl)cc1 |w:5.5|
Structure:
Search PDB for entries with ligand similarity: