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Target
Protein artemis
Ligand
BDBM67836
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule inhibitors originally identified via uHTS of Artemis endonuclease activity via a fluorescence intensity assay
IC50
20000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of small molecule inhibitors originally identified via uHTS of Artemis endonuclease activity via a fluorescence intensity assay PubChem Bioassay (2013)[AID] 
Target
Name:
Protein artemis
Synonyms:
ARTEMIS | ASCID | DCLRE1C | DCR1C_HUMAN | SCIDA | SNM1C | protein artemis isoform a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
78427.91
Organism:
Homo sapiens (Human)
Description:
gi_76496497
Residue:
692
Sequence:
MSSFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRRLECSLKVYLYCSPVTKELLLTSPKYRFWKKRIISIEIETPTQISLVDEASGEKEEIVVTLLPAGHCPGSVMFLFQGNNGTVLYTGDFRLAQGEAARMELLHSGGRVKDIQSVYLDTTFCDPRFYQIPSREECLSGVLELVRSWITRSPYHVVWLNCKAAYGYEYLFTNLSEELGVQVHVNKLDMFRNMPEILHHLTTDRNTQIHACRHPKAEEYFQWSKLPCGITSRNRIPLHIISIKPSTMWFGERSRKTNVIVRTGESSYRACFSFHSSYSEIKDFLSYLCPVNAYPNVIPVGTTMDKVVEILKPLCRSSQSTEPKYKPLGKLKRARTVHRDSEEEDDYLFDDPLPIPLRHKVPYPETFHPEVFSMTAVSEKQPEKLRQTPGCCRAECMQSSRFTNFVDCEESNSESEEEVGIPASLQGDLGSVLHLQKADGDVPQWEVFFKRNDEITDESLENFPSSTVAGGSQSPKLFSDSDGESTHISSQNSSQSTHITEQGSQGWDSQSDTVLLSSQERNSGDITSLDKADYRPTIKENIPASLMEQNVICPKDTYSDLKSRDKDVTIVPSTGEPTTLSSETHIPEEKSLLNLSTNADSQSSSDFEVPSTPEAELPKREHLQYLYEKLATGESIAVKKRKCSLLDT
  
Inhibitor
Name:
BDBM67836
Synonyms:
3-(phenylcarbonyl)-2-(trifluoromethyl)benzo[f][1]benzofuran-4,9-dione | 3-benzoyl-2-(trifluoromethyl)benzo[f][1]benzofuran-4,9-dione | 3-benzoyl-2-(trifluoromethyl)benzo[f]benzofuran-4,9-dione | 3-benzoyl-2-(trifluoromethyl)benzo[f]benzofuran-4,9-quinone | 3-benzoyl-2-(trifluoromethyl)naphtho[2,3-b]furan-4,9-dione | MLS000533785 | SMR000141223 | cid_1207959
Type:
Small organic molecule
Emp. Form.:
C20H9F3O4
Mol. Mass.:
370.2783
SMILES:
FC(F)(F)c1oc2c(c1C(=O)c1ccccc1)C(=O)c1ccccc1C2=O
Structure:
Search PDB for entries with ligand similarity: