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Target
Protein artemis
Ligand
BDBM34693
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule inhibitors originally identified via uHTS of Artemis endonuclease activity via a fluorescence intensity assay
IC50
1120±n/a nM
Citation
 PubChem, PC Dose Response confirmation of small molecule inhibitors originally identified via uHTS of Artemis endonuclease activity via a fluorescence intensity assay PubChem Bioassay (2013)[AID] 
Target
Name:
Protein artemis
Synonyms:
ARTEMIS | ASCID | DCLRE1C | DCR1C_HUMAN | SCIDA | SNM1C | protein artemis isoform a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
78427.91
Organism:
Homo sapiens (Human)
Description:
gi_76496497
Residue:
692
Sequence:
MSSFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRRLECSLKVYLYCSPVTKELLLTSPKYRFWKKRIISIEIETPTQISLVDEASGEKEEIVVTLLPAGHCPGSVMFLFQGNNGTVLYTGDFRLAQGEAARMELLHSGGRVKDIQSVYLDTTFCDPRFYQIPSREECLSGVLELVRSWITRSPYHVVWLNCKAAYGYEYLFTNLSEELGVQVHVNKLDMFRNMPEILHHLTTDRNTQIHACRHPKAEEYFQWSKLPCGITSRNRIPLHIISIKPSTMWFGERSRKTNVIVRTGESSYRACFSFHSSYSEIKDFLSYLCPVNAYPNVIPVGTTMDKVVEILKPLCRSSQSTEPKYKPLGKLKRARTVHRDSEEEDDYLFDDPLPIPLRHKVPYPETFHPEVFSMTAVSEKQPEKLRQTPGCCRAECMQSSRFTNFVDCEESNSESEEEVGIPASLQGDLGSVLHLQKADGDVPQWEVFFKRNDEITDESLENFPSSTVAGGSQSPKLFSDSDGESTHISSQNSSQSTHITEQGSQGWDSQSDTVLLSSQERNSGDITSLDKADYRPTIKENIPASLMEQNVICPKDTYSDLKSRDKDVTIVPSTGEPTTLSSETHIPEEKSLLNLSTNADSQSSSDFEVPSTPEAELPKREHLQYLYEKLATGESIAVKKRKCSLLDT
  
Inhibitor
Name:
BDBM34693
Synonyms:
3-(4-Chloro-benzoyl)-2-methyl-naphtho[1,2-b]furan-4,5-dione | 3-(4-chlorobenzoyl)-2-methyl-benzo[g]benzofuran-4,5-quinone | 3-(4-chlorobenzoyl)-2-methylbenzo[g][1]benzofuran-4,5-dione | 3-(4-chlorophenyl)carbonyl-2-methyl-benzo[g][1]benzofuran-4,5-dione | 3-[(4-chlorophenyl)-oxomethyl]-2-methylbenzo[g]benzofuran-4,5-dione | MLS000554107 | SMR000146424 | cid_3698299
Type:
Small organic molecule
Emp. Form.:
C20H11ClO4
Mol. Mass.:
350.752
SMILES:
Cc1oc-2c(c1C(=O)c1ccc(Cl)cc1)C(=O)C(=O)c1ccccc-21
Structure:
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