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Target
Oxysterols receptor LXR-beta
Ligand
BDBM93778
Substrate
n/a
Meas. Tech.
Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based dose response assay to identify agonists of the Liver-X-Receptor (LXR).
EC50
67525±n/a nM
Citation
 PubChem, PC Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based dose response assay to identify agonists of the Liver-X-Receptor (LXR). PubChem Bioassay (2013)[AID] 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM93778
Synonyms:
(2Z)-2-[(3-chloro-4-methyl-anilino)methylene]-4,4,4-trifluoro-1-(2-furyl)butane-1,3-dione | (2Z)-2-[(3-chloro-4-methylanilino)methylidene]-4,4,4-trifluoro-1-(2-furanyl)butane-1,3-dione | (2Z)-2-[(3-chloro-4-methylanilino)methylidene]-4,4,4-trifluoro-1-(furan-2-yl)butane-1,3-dione | (2Z)-2-[[(3-chloranyl-4-methyl-phenyl)amino]methylidene]-4,4,4-tris(fluoranyl)-1-(furan-2-yl)butane-1,3-dione | 2-{[(3-chloro-4-methylphenyl)amino]methylene}-4,4,4-trifluoro-1-(2-furyl)-1,3-butanedione | MLS000579302 | SMR000198583 | cid_2149945
Type:
Small organic molecule
Emp. Form.:
C16H11ClF3NO3
Mol. Mass.:
357.712
SMILES:
Cc1ccc(cc1Cl)N=CC(C(=O)c1ccco1)C(=O)C(F)(F)F |w:8.8|
Structure:
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