Reaction Details Report a problem with these data
Target
Oxysterols receptor LXR-beta
Ligand
BDBM49248
Substrate
n/a
Meas. Tech.
Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based dose response screening assay to identify agonists of the Liver-X-Receptor (LXR)
EC50
67541±n/a nM
Citation
 PubChem, PC Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based dose response screening assay to identify agonists of the Liver-X-Receptor (LXR) PubChem Bioassay (2013)[AID] 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM49248
Synonyms:
4-amino-2-(benzylthio)pyrimidine-5-carboxylic acid ethyl ester | 4-amino-2-(phenylmethylthio)-5-pyrimidinecarboxylic acid ethyl ester | MLS000099282 | SMR000073548 | cid_251641 | ethyl 4-amino-2-(benzylthio)-5-pyrimidinecarboxylate | ethyl 4-amino-2-benzylsulfanylpyrimidine-5-carboxylate | ethyl 4-azanyl-2-(phenylmethylsulfanyl)pyrimidine-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C14H15N3O2S
Mol. Mass.:
289.353
SMILES:
CCOC(=O)c1cnc(SCc2ccccc2)nc1N
Structure:
Search PDB for entries with ligand similarity: