Reaction Details Report a problem with these data
Target
Oxysterols receptor LXR-beta
Ligand
BDBM49546
Substrate
n/a
Meas. Tech.
Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based screening assay to identify agonists of the Liver-X-Receptor (LXR).
IC50
67588±n/a nM
Citation
 PubChem, PC Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based screening assay to identify agonists of the Liver-X-Receptor (LXR). PubChem Bioassay (2013)[AID] 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM49546
Synonyms:
2-chlorobenzoic acid [(Z)-[amino(phenyl)methylene]amino] ester | 2-chlorobenzoic acid [(Z)-[amino(phenyl)methylidene]amino] ester | MLS000576943 | N'-[(2-chlorobenzoyl)oxy]benzenecarboximidamide | SMR000185421 | [(Z)-[amino(phenyl)methylidene]amino] 2-chlorobenzoate | [(Z)-[azanyl(phenyl)methylidene]amino] 2-chloranylbenzoate | cid_5332683
Type:
Small organic molecule
Emp. Form.:
C14H11ClN2O2
Mol. Mass.:
274.702
SMILES:
NC(=NOC(=O)c1ccccc1Cl)c1ccccc1 |w:2.2|
Structure:
Search PDB for entries with ligand similarity: