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Target
Urea transporter 1
Ligand
BDBM115194
Substrate
n/a
Meas. Tech.
UT-B Inhibition Assay
IC50
>5.0e+4±n/a nM
Citation
 Esteva-Font, C; Phuan, PW; Anderson, MO; Verkman, AS A small molecule screen identifies selective inhibitors of urea transporter UT-A. Chem Biol 20:1235-44 (2013) [PubMed]  Article 
Target
Name:
Urea transporter 1
Synonyms:
Slc14a1 | UT11 | UT1_RAT | UT3 | Urea transporter B (UT-B)
Type:
Protein
Mol. Mass.:
42037.85
Organism:
Rattus norvegicus (Rat)
Description:
n/a
Residue:
384
Sequence:
MEDIPTMVKVDRGESQILSCRGRRCGLKVLGYVTGDMKEFANWLKDKPVVLQFMDWILRGISQVVFVSNPISGILILAGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYNATLVGILMAVFSDKGDYFWWLIFPVSAMSMTCPVFSSALSSLFSKWDLPVFTLPFNMALSLYLSATGHYNTFFPSKLFMPVSSVPNITWSELSALELLKSLPVGVGQIYGCDNPWTGAIFLCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFKDIYSGLWGFNSSLACIAIGGMFMALTWQTHLLALACALFTAYFGACMTHLMAAVHLPACTWSFCLATLLFLLLTTENPNIYRMPLSKVTYSEENRIFYLQNKKRVVDSPL
  
Inhibitor
Name:
BDBM115194
Synonyms:
4‐(4,5‐dihydro‐1,3‐thiazol‐2‐ylsulfanyl)‐N‐(3,4‐ dimethoxyphenyl)‐6‐[(3,4‐dimethoxyphenyl)methyl]‐ 1,3,5‐triazin‐2‐amine | UT-A1 inhibitor C1
Type:
Small organic molecule
Emp. Form.:
C23H25N5O4S2
Mol. Mass.:
499.606
SMILES:
COc1ccc(Cc2nc(Nc3ccc(OC)c(OC)c3)nc(SC3=NCCS3)n2)cc1OC |t:25|
Structure:
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