Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM117020
Substrate
n/a
Meas. Tech.
Radioligand Binding Assays
pH
7.4±0
Temperature
298.15±0 K
IC50
1.2±0.0 nM
Citation
 Teegarden, B; Chapman, D; Choi, J; Feichtinger, K; Han, S; Jayakumar, H; Tran, T; Xu, J; Zou, N Primary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto US Patent  US8664258 Publication Date 3/4/2014 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM117020
Synonyms:
US8664258, 77
Type:
Small organic molecule
Emp. Form.:
C18H16BrClN4O3S
Mol. Mass.:
483.767
SMILES:
Cn1ncc(Cl)c1-c1cc(NC(=O)C(=O)c2cc(Br)cs2)ccc1OCCN |(7.61,.31,;6.84,-1.03,;7.75,-2.27,;6.84,-3.52,;5.38,-3.04,;4.29,-4.13,;5.38,-1.5,;4.05,-.73,;2.71,-1.5,;1.38,-.73,;.05,-1.5,;-1.29,-.73,;-1.29,.81,;-2.62,-1.5,;-2.62,-3.04,;-3.96,-.73,;-3.88,.81,;-5.31,1.36,;-5.71,2.85,;-6.28,.16,;-5.44,-1.13,;1.38,.81,;2.71,1.58,;4.05,.81,;5.38,1.58,;5.38,3.12,;6.87,3.52,;7.96,2.43,)|
Structure:
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